View source for 8ok2


==Bipartite interaction of TOPBP1 with the GINS complex==
<StructureSection load='8ok2' size='340' side='right'caption='[[8ok2]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ok2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OK2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ok2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ok2 OCA], [https://pdbe.org/8ok2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ok2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ok2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ok2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSF1_HUMAN PSF1_HUMAN] The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.<ref>PMID:17417653</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Day M]]
[[Category: Oliver AW]]
[[Category: Pearl LH]]