View source for 8omq


==DNA-unbound MutSbeta-ATP complex (straight clamp form)==
<StructureSection load='8omq' size='340' side='right'caption='[[8omq]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8omq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OMQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8omq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8omq OCA], [https://pdbe.org/8omq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8omq RCSB], [https://www.ebi.ac.uk/pdbsum/8omq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8omq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MSH3_HUMAN MSH3_HUMAN] MSH3-related attenuated familial adenomatous polyposis. Disease susceptibility is associated with variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MSH3_HUMAN MSH3_HUMAN] Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Daub H]]
[[Category: Dominguez C]]
[[Category: Felsenfeld DP]]
[[Category: Finley M]]
[[Category: Haque T]]
[[Category: Iyer RR]]
[[Category: Lee J-H]]
[[Category: Monteagudo E]]
[[Category: Neudegger T]]
[[Category: Plotnikov N]]
[[Category: Prasad BC]]
[[Category: Steinbacher S]]
[[Category: Sztyler A]]
[[Category: Thieulin-Pardo G]]
[[Category: Thomsen M]]
[[Category: Vogt TF]]
[[Category: Wilkinson H]]