View source for 8onu


==Solution structure of thanatin analogue 7 in complex with LptAm(Ab)1.0==
<StructureSection load='8onu' size='340' side='right'caption='[[8onu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8onu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii] and [https://en.wikipedia.org/wiki/Podisus_maculiventris Podisus maculiventris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ONU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ONU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4FO:(2R)-2,4-DIAMINOBUTANOIC+ACID'>4FO</scene>, <scene name='pdbligand=DAB:2,4-DIAMINOBUTYRIC+ACID'>DAB</scene>, <scene name='pdbligand=EU0:1-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]guanidine'>EU0</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=LE1:3-SULFANYL-L-VALINE'>LE1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8onu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8onu OCA], [https://pdbe.org/8onu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8onu RCSB], [https://www.ebi.ac.uk/pdbsum/8onu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8onu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/V5VEZ9_ACIBA V5VEZ9_ACIBA] Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.[HAMAP-Rule:MF_01914]
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</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Large Structures]]
[[Category: Podisus maculiventris]]
[[Category: Moehle K]]
[[Category: Oi KK]]
[[Category: Zerbe O]]