View source for 8owy


==Crystal structure of METTL6 mutant 40-269 bound to SAH==
<StructureSection load='8owy' size='340' side='right'caption='[[8owy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8owy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OWY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8owy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8owy OCA], [https://pdbe.org/8owy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8owy RCSB], [https://www.ebi.ac.uk/pdbsum/8owy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8owy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/METL6_HUMAN METL6_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862464, PubMed:34922197). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557).<ref>PMID:32923617</ref> <ref>PMID:34268557</ref> <ref>PMID:34862464</ref> <ref>PMID:34922197</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Basu S]]
[[Category: Dolce LG]]
[[Category: Kowalinski E]]
[[Category: Throll P]]