View source for 8oxr


==Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A==
<StructureSection load='8oxr' size='340' side='right'caption='[[8oxr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OXR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oxr OCA], [https://pdbe.org/8oxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oxr RCSB], [https://www.ebi.ac.uk/pdbsum/8oxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oxr ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/THS7A_HUMAN THS7A_HUMAN] Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).<ref>PMID:25394321</ref> <ref>PMID:29555830</ref> 
== Function ==
[https://www.uniprot.org/uniprot/THS7A_HUMAN THS7A_HUMAN] Plays a role in actin cytoskeleton rearrangement.<ref>PMID:27214550</ref>   The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.<ref>PMID:22194972</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bochel A]]
[[Category: Chojnowski G]]
[[Category: Mortensen SA]]
[[Category: Wilmanns M]]