View source for 8oxs


==Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions)==
<StructureSection load='8oxs' size='340' side='right'caption='[[8oxs]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8oxs]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OXS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oxs OCA], [https://pdbe.org/8oxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oxs RCSB], [https://www.ebi.ac.uk/pdbsum/8oxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oxs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHTA_VIBCH CHTA_VIBCH] The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae O1]]
[[Category: Cordara G]]
[[Category: Heim JB]]
[[Category: Kersten F]]
[[Category: Krengel U]]