View source for 8ozs


==Populus tremula stable protein 1 with N-terminal binding peptide extension with hemin==
<StructureSection load='8ozs' size='340' side='right'caption='[[8ozs]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ozs]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_tremula Populus tremula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OZS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ozs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ozs OCA], [https://pdbe.org/8ozs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ozs RCSB], [https://www.ebi.ac.uk/pdbsum/8ozs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ozs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9AR79_POPTN Q9AR79_POPTN] 
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== Publication Abstract from PubMed ==
Enzymes have gained their unique efficiency and catalytic activity through billions of years of evolution, perfecting their active site to a desired reaction. Inspired by nature, a novel enzyme-mimicking platform is designed based on stable protein 1 (SP1) to create a nano-compartment that mimics peroxidase activity. The biohybrid reveals enhanced activity over the hemin cofactor alone and improved stability in organic solvents in comparison to native peroxidase. Furthermore, the utilization of the obtained biohybrid in an optical glucose biosensing platform is shown. The biohybrid crystallographic structure is solved, indicating that the SP1 structure is not affected by the hemin coordination. This work opens the path for developing new cofactor binding centers in engineered protein scaffolds for various artificial catalytic processes.

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties.,Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O Small Sci. 2024 Mar 19;4(6):2400025. doi: 10.1002/smsc.202400025. eCollection , 2024 Jun. PMID:40212758<ref>PMID:40212758</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8ozs" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Populus tremula]]
[[Category: Adir N]]
[[Category: Bachar O]]
[[Category: Sklyar J]]
[[Category: Yehezkeli O]]
[[Category: Zeibaq Y]]