View source for 8p3a


==bacteriophage T5 l-alanoyl-d-glutamate peptidase Zn2+/Ca2+ form==
<StructureSection load='8p3a' size='340' side='right'caption='[[8p3a]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8p3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T5 Escherichia phage T5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P3A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p3a OCA], [https://pdbe.org/8p3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p3a RCSB], [https://www.ebi.ac.uk/pdbsum/8p3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p3a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT5 ENLYS_BPT5] Endolysin with L-alanyl-D-glutamate peptidase activity that degrades host peptidoglycans and participates with the holin in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer by hydrolyzing the link between L-alanine and D-glutamate residues.<ref>PMID:19919545</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage T5]]
[[Category: Large Structures]]
[[Category: Kutyshenko VP]]
[[Category: Mikoulinskaia GV]]
[[Category: Prokhorov DA]]