View source for 8phx


==Receiver Domain of the Hybrid Histidine Kinase Sln1 of Candida albicans==
<StructureSection load='8phx' size='340' side='right'caption='[[8phx]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8phx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PHX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8phx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8phx OCA], [https://pdbe.org/8phx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8phx RCSB], [https://www.ebi.ac.uk/pdbsum/8phx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8phx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLN1_CANAL SLN1_CANAL] Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.<ref>PMID:10572127</ref> <ref>PMID:11368790</ref> <ref>PMID:14734021</ref> <ref>PMID:17038117</ref> <ref>PMID:9493379</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candida albicans SC5314]]
[[Category: Large Structures]]
[[Category: Casino P]]
[[Category: Paredes-Martinez F]]