View source for 8pk3


==CryoEM reconstruction of hemagglutinin HK68 of Influenza A virus bound to an Affimer reagent==
<StructureSection load='8pk3' size='340' side='right'caption='[[8pk3]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pk3]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PK3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pk3 OCA], [https://pdbe.org/8pk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pk3 RCSB], [https://www.ebi.ac.uk/pdbsum/8pk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pk3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
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</StructureSection>
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Debski-Antoniak O]]
[[Category: Flynn A]]
[[Category: Fontana J]]
[[Category: Klebl DP]]
[[Category: Muench S]]
[[Category: Tiede C]]
[[Category: Tomlinson D]]