View source for 8pk6


==INTS13 complex with ZNF655==
<StructureSection load='8pk6' size='340' side='right'caption='[[8pk6]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pk6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PK6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pk6 OCA], [https://pdbe.org/8pk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pk6 RCSB], [https://www.ebi.ac.uk/pdbsum/8pk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pk6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INT13_HUMAN INT13_HUMAN] Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).<ref>PMID:15737938</ref> <ref>PMID:23097494</ref> <ref>PMID:23904267</ref> <ref>PMID:23097494</ref> <ref>PMID:23904267</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Integrator complex attenuates gene expression via the premature termination of RNA polymerase II (RNAP2) at promoter-proximal pausing sites. It is required for stimulus response, cell differentiation, and neurodevelopment, but how gene-specific and adaptive regulation by Integrator is achieved remains unclear. Here, we identify two sites on human Integrator subunits 13/14 that serve as binding hubs for sequence-specific transcription factors (TFs) and other transcription effector complexes. When Integrator is attached to paused RNAP2, these hubs are positioned upstream of the transcription bubble, consistent with simultaneous TF-promoter tethering. The TFs co-localize with Integrator genome-wide, increase Integrator abundance on target genes, and co-regulate responsive transcriptional programs. For instance, sensory cilia formation induced by glucose starvation depends on Integrator-TF contacts. Our data suggest TF-mediated promoter recruitment of Integrator as a widespread mechanism for targeted transcription regulation.

Basis of gene-specific transcription regulation by the Integrator complex.,Sabath K, Nabih A, Arnold C, Moussa R, Domjan D, Zaugg JB, Jonas S Mol Cell. 2024 Jun 17:S1097-2765(24)00474-X. doi: 10.1016/j.molcel.2024.05.027. PMID:38906142<ref>PMID:38906142</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8pk6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jonas S]]
[[Category: Sabath K]]