View source for 8pmd


==Nucleotide-bound BSEP in nanodiscs==
<StructureSection load='8pmd' size='340' side='right'caption='[[8pmd]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PMD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pmd OCA], [https://pdbe.org/8pmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pmd RCSB], [https://www.ebi.ac.uk/pdbsum/8pmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pmd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bang-Sorensen R]]
[[Category: Irobalieva RN]]
[[Category: Kowal J]]
[[Category: Lancien L]]
[[Category: Liu H]]
[[Category: Locher KP]]
[[Category: Ni D]]
[[Category: Nosol K]]
[[Category: Stahlberg H]]
[[Category: Stieger B]]