View source for 8pnk


==Crystal structure of the Ded1p RecA1 domain==
<StructureSection load='8pnk' size='340' side='right'caption='[[8pnk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PNK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pnk OCA], [https://pdbe.org/8pnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pnk RCSB], [https://www.ebi.ac.uk/pdbsum/8pnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pnk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DED1_YEAST DED1_YEAST] ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Has weak ATP-dependent affinity for dsRNA, but strong ATP-dependent affinity for ssRNA. Acts as a virus host factor involved in the replication of the MBV and the L-A viruses by promoting the negative-strand RNA synthesis. May be involved in recognition of the preinitiation complex and DNA binding of the RNA polymerase III and play a role in mRNA splicing.<ref>PMID:10364207</ref> <ref>PMID:11069307</ref> <ref>PMID:14671320</ref> <ref>PMID:14763975</ref> <ref>PMID:15064363</ref> <ref>PMID:15201868</ref> <ref>PMID:16216083</ref> <ref>PMID:18332124</ref> <ref>PMID:1996139</ref> <ref>PMID:7835345</ref> <ref>PMID:9045610</ref> <ref>PMID:9144215</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Huebner J]]
[[Category: Sprangers R]]