View source for 8puh


==Structure of the immature HTLV-1 CA lattice from full-length Gag VLPs: CA-CTD refinement==
<StructureSection load='8puh' size='340' side='right'caption='[[8puh]], [[Resolution|resolution]] 6.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8puh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PUH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8puh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8puh OCA], [https://pdbe.org/8puh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8puh RCSB], [https://www.ebi.ac.uk/pdbsum/8puh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8puh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G9BL35_9DELA G9BL35_9DELA] Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.[ARBA:ARBA00002374]  Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.[ARBA:ARBA00037500]  Matrix protein.[ARBA:ARBA00003230]  The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.[ARBA:ARBA00037194]
__TOC__
</StructureSection>
[[Category: Human T-cell leukemia virus type I]]
[[Category: Large Structures]]
[[Category: Chernikova D]]
[[Category: Dick RA]]
[[Category: Mansky LM]]
[[Category: Obr M]]
[[Category: Percipalle M]]
[[Category: Pinke G]]
[[Category: Porley D]]
[[Category: Schur FKM]]
[[Category: Thader A]]
[[Category: Yang H]]