View source for 8pui


==human PHOX2B C-terminal domain including the polyA fragment at 298K==
<StructureSection load='8pui' size='340' side='right'caption='[[8pui]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PUI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pui OCA], [https://pdbe.org/8pui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pui RCSB], [https://www.ebi.ac.uk/pdbsum/8pui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pui ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PHX2B_HUMAN PHX2B_HUMAN] Neuroblastoma;Congenital central hypoventilation syndrome;Hirschsprung disease-ganglioneuroblastoma syndrome;Haddad syndrome. The disease is caused by variants affecting the gene represented in this entry.  Disease susceptibility is associated with variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PHX2B_HUMAN PHX2B_HUMAN] Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Anton R]]
[[Category: Babu M]]
[[Category: Cabrita EJ]]
[[Category: Felix S]]
[[Category: Oroz J]]
[[Category: Pantoja-Uceda D]]
[[Category: Tinnefeld P]]
[[Category: Trevino MA]]
[[Category: Vera AM]]
[[Category: Zweckstetter M]]