View source for 8pv9


==Structure of DPS determined by cryoEM at 100 keV==
<StructureSection load='8pv9' size='340' side='right'caption='[[8pv9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PV9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pv9 OCA], [https://pdbe.org/8pv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pv9 RCSB], [https://www.ebi.ac.uk/pdbsum/8pv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pv9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPS_ECOLI DPS_ECOLI] During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.<ref>PMID:1340475</ref> <ref>PMID:10403254</ref> <ref>PMID:15205421</ref> <ref>PMID:15534364</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Cannone G]]
[[Category: Chen S]]
[[Category: Dalby J]]
[[Category: Dickerson JL]]
[[Category: El-Gomati MM]]
[[Category: Gittins O]]
[[Category: Henderson R]]
[[Category: Hutchings KA]]
[[Category: Lee Y]]
[[Category: McMullan G]]
[[Category: Meffert M]]
[[Category: Mihaylov D]]
[[Category: Naydenova K]]
[[Category: Peet MJ]]
[[Category: Russo CJ]]
[[Category: Schulze-Briese C]]
[[Category: Sobhy M]]
[[Category: Wells T]]
[[Category: Wilson H]]
[[Category: Yamashita K]]