View source for 8pve


==Structure of AHIR determined by cryoEM at 100 keV==
<StructureSection load='8pve' size='340' side='right'caption='[[8pve]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pve OCA], [https://pdbe.org/8pve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pve RCSB], [https://www.ebi.ac.uk/pdbsum/8pve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pve ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ILVC_THET2 ILVC_THET2] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Cannone G]]
[[Category: Chen S]]
[[Category: Dalby J]]
[[Category: Dickerson JL]]
[[Category: El-Gomati MM]]
[[Category: Gittins O]]
[[Category: Henderson R]]
[[Category: Hutchings KA]]
[[Category: Lee Y]]
[[Category: McMullan G]]
[[Category: Meffert M]]
[[Category: Mihaylov D]]
[[Category: Naydenova K]]
[[Category: Peet MJ]]
[[Category: Russo CJ]]
[[Category: Schulze-Briese C]]
[[Category: Sobhy M]]
[[Category: Wells T]]
[[Category: Wilson H]]
[[Category: Yamashita K]]