View source for 8pvi


==Structure of PaaZ determined by cryoEM at 100 keV==
<StructureSection load='8pvi' size='340' side='right'caption='[[8pvi]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pvi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pvi OCA], [https://pdbe.org/8pvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pvi RCSB], [https://www.ebi.ac.uk/pdbsum/8pvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pvi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Cannone G]]
[[Category: Chen S]]
[[Category: Dalby J]]
[[Category: Dickerson JL]]
[[Category: El-Gomati MM]]
[[Category: Gittins O]]
[[Category: Henderson R]]
[[Category: Hutchings KA]]
[[Category: Lee Y]]
[[Category: McMullan G]]
[[Category: Meffert M]]
[[Category: Mihaylov D]]
[[Category: Naydenova K]]
[[Category: Peet MJ]]
[[Category: Russo CJ]]
[[Category: Schulze-Briese C]]
[[Category: Sobhy M]]
[[Category: Wells T]]
[[Category: Wilson H]]
[[Category: Yamashita K]]