View source for 8pxb


==Cryo-EM structure of horse NHE9 with a extracellular loop==
<StructureSection load='8pxb' size='340' side='right'caption='[[8pxb]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PXB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pxb OCA], [https://pdbe.org/8pxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pxb RCSB], [https://www.ebi.ac.uk/pdbsum/8pxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pxb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SL9A9_HORSE SL9A9_HORSE] Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (PubMed:33118634). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (By similarity). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity).[UniProtKB:Q8BZ00][UniProtKB:Q8IVB4]<ref>PMID:33118634</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Large Structures]]
[[Category: Drew D]]
[[Category: Kokane S]]
[[Category: Matsuoka R]]
[[Category: Meier P]]