View source for 8pxw


==Structure of the WW domain tandem of PRPF40A==
<StructureSection load='8pxw' size='340' side='right'caption='[[8pxw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8pxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pxw OCA], [https://pdbe.org/8pxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pxw RCSB], [https://www.ebi.ac.uk/pdbsum/8pxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pxw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Martinez-Lumbreras S]]
[[Category: Sattler M]]