View source for 8qat


==Cryo-EM structure of Fts-Hook3-FHIP1B at 3.2 A resolution.==
<StructureSection load='8qat' size='340' side='right'caption='[[8qat]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QAT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qat OCA], [https://pdbe.org/8qat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qat RCSB], [https://www.ebi.ac.uk/pdbsum/8qat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qat ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HOOK3_HUMAN HOOK3_HUMAN] Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.<ref>PMID:11238449</ref> <ref>PMID:17237231</ref> <ref>PMID:18799622</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abid Ali F]]
[[Category: Carter AP]]