View source for 8qb0


==Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 2==
<StructureSection load='8qb0' size='340' side='right'caption='[[8qb0]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qb0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QB0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qb0 OCA], [https://pdbe.org/8qb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qb0 RCSB], [https://www.ebi.ac.uk/pdbsum/8qb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qb0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cazzanelli G]]
[[Category: Dalle Vedove A]]
[[Category: Lolli G]]