View source for 8qc3


==Crystal structure of oxidoreductive sulfoquinovosidase from Arthrobacter sp. U41 (ArSqgA)in complex with co-factor NAD+==
<StructureSection load='8qc3' size='340' side='right'caption='[[8qc3]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_sp._U41 Arthrobacter sp. U41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QC3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qc3 OCA], [https://pdbe.org/8qc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qc3 RCSB], [https://www.ebi.ac.uk/pdbsum/8qc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qc3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1C9WRL0_9MICC A0A1C9WRL0_9MICC] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The sulfosugar sulfoquinovose (SQ) is produced by photosynthetic plants, algae, and cyanobacteria on a scale of 10 billion tons per annum. Its degradation, which is essential to allow cycling of its constituent carbon and sulfur, involves specialized glycosidases termed sulfoquinovosidases (SQases), which release SQ from sulfolipid glycoconjugates, so SQ can enter catabolism pathways. However, many SQ catabolic gene clusters lack a gene encoding a classical SQase. Here, we report the discovery of a new family of SQases that use an atypical oxidoreductive mechanism involving NAD(+) as a catalytic cofactor. Three-dimensional X-ray structures of complexes with SQ and NAD(+) provide insight into the catalytic mechanism, which involves transient oxidation at C3. Bioinformatic survey reveals this new family of NAD(+)-dependent SQases occurs within sulfoglycolytic and sulfolytic gene clusters that lack classical SQases and is distributed widely including within Roseobacter clade bacteria, suggesting an important contribution to marine sulfur cycling.

Widespread Family of NAD(+)-Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism.,Kaur A, Pickles IB, Sharma M, Madeido Soler N, Scott NE, Pidot SJ, Goddard-Borger ED, Davies GJ, Williams SJ J Am Chem Soc. 2023 Dec 27;145(51):28216-28223. doi: 10.1021/jacs.3c11126. Epub , 2023 Dec 15. PMID:38100472<ref>PMID:38100472</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8qc3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arthrobacter sp. U41]]
[[Category: Large Structures]]
[[Category: Davies GJ]]
[[Category: Sharma M]]