View source for 8qdo


==Crystal structure of the tegument protein UL82 (pp71) from Human Cytomegalovirus==
<StructureSection load='8qdo' size='340' side='right'caption='[[8qdo]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qdo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QDO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qdo OCA], [https://pdbe.org/8qdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qdo RCSB], [https://www.ebi.ac.uk/pdbsum/8qdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qdo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PP71_HCMVA PP71_HCMVA] Stimulates viral immediate-early (IE) transcription. Plays a role in the inhibition of the host innate repsonse by targeting STING1 and thus the cGAS-STING pathway (PubMed:28132838, PubMed:32581105). Counteracts also host DAXX-mediated repression of viral transcription. Displaces a DAXX-binding protein, ATRX, from nuclear domain 10 sites (ND10) shortly after infection (PubMed:18922870). Increases the basal level of SUMOylated DAXX in infected cells (PubMed:19369322). Stimulates quiescent cells to re-enter the cell cycle, proceed through G1 and enter the S phase (PubMed:12610120). Interacts with hypophosphorylated forms of RB1 and induces their degradation by the proteasome without involving ubiquitin conjugation (PubMed:12626766).<ref>PMID:12610120</ref> <ref>PMID:12626766</ref> <ref>PMID:18922870</ref> <ref>PMID:19369322</ref> <ref>PMID:28132838</ref> <ref>PMID:32581105</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human betaherpesvirus 5]]
[[Category: Large Structures]]
[[Category: Bresch IP]]
[[Category: Eberhage J]]
[[Category: Eschenburg S]]
[[Category: Reubold TF]]