View source for 8qhm


==DNA mimic Foldamer with sticky ends==
<StructureSection load='8qhm' size='340' side='right'caption='[[8qhm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qhm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QHM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qhm OCA], [https://pdbe.org/8qhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qhm RCSB], [https://www.ebi.ac.uk/pdbsum/8qhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qhm ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
DNA mimic foldamers based on aromatic oligoamide helices bearing anionic phosphonate side chains have been shown to bind to DNA-binding proteins sometimes orders of magnitude better than DNA itself. Here, we introduce new features in the DNA mimic foldamers to facilitate structural investigations of their interactions with proteins. Thirteen new foldamer sequences have been synthesized and characterized using NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results show that foldamer helix handedness can be quantitatively biased by means of a single stereogenic center, that the foldamer structure can be made C(2)-symmetrical as in palindromic B-DNA sequences, and that associations between foldamer helices can be promoted utilizing dedicated C-terminal residues that act as sticky ends in B-DNA structures.

Enhancing the Features of DNA Mimic Foldamers for Structural Investigations.,Corvaglia V, Wu J, Deepak D, Loos M, Huc I Chemistry. 2024 Mar 15;30(16):e202303650. doi: 10.1002/chem.202303650. Epub 2024 , Jan 30. PMID:38193643<ref>PMID:38193643</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 8qhm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Deepak D]]
[[Category: Huc I]]
[[Category: Loos M]]