View source for 8qkb


==Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777==
<StructureSection load='8qkb' size='340' side='right'caption='[[8qkb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qkb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D1R:NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE'>D1R</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkb OCA], [https://pdbe.org/8qkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkb RCSB], [https://www.ebi.ac.uk/pdbsum/8qkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chapman HN]]
[[Category: Ewert W]]
[[Category: Falke S]]
[[Category: Guenther S]]
[[Category: Hinrichs W]]
[[Category: Karnicar K]]
[[Category: Lieske J]]
[[Category: Lindic N]]
[[Category: Loboda J]]
[[Category: Meents A]]
[[Category: Reinke PYA]]
[[Category: Sekirnik A]]
[[Category: Turk D]]
[[Category: Usenik A]]