View source for 8qky


==Bacteriophage T5 dUTPase==
<StructureSection load='8qky' size='340' side='right'caption='[[8qky]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qky]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T5 Escherichia phage T5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qky OCA], [https://pdbe.org/8qky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qky RCSB], [https://www.ebi.ac.uk/pdbsum/8qky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qky ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_BPT5 DUT_BPT5] This enzyme decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into viral progeny DNA. This activity is sufficient to exclude uracil from the DNA during phage replication. In the case of dUTPase mutant phages, the host dUTPase activity is not sufficient to exclude uracil from T5 DNA and uracil are incorporated, leading to decreased phage viability.<ref>PMID:381286</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage T5]]
[[Category: Large Structures]]
[[Category: Dzhus UF]]
[[Category: Gabdulkhakov AG]]
[[Category: Glukhov AS]]
[[Category: Selikhanov GK]]