View source for 8ql1


==Crystal structure of the human MDN1-MIDAS/NLE1-UBL complex==
<StructureSection load='8ql1' size='340' side='right'caption='[[8ql1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ql1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QL1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ql1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ql1 OCA], [https://pdbe.org/8ql1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ql1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ql1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ql1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NLE1_HUMAN NLE1_HUMAN] Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fiorentino F]]
[[Category: Hurt E]]
[[Category: Sinning I]]
[[Category: Wild K]]