View source for 8qld


==Bacteriophage T5 dUTPase mutant with loop deletion (30-35 aa)==
<StructureSection load='8qld' size='340' side='right'caption='[[8qld]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qld]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T5 Escherichia phage T5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QLD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qld OCA], [https://pdbe.org/8qld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qld RCSB], [https://www.ebi.ac.uk/pdbsum/8qld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qld ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_BPT5 DUT_BPT5] This enzyme decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into viral progeny DNA. This activity is sufficient to exclude uracil from the DNA during phage replication. In the case of dUTPase mutant phages, the host dUTPase activity is not sufficient to exclude uracil from T5 DNA and uracil are incorporated, leading to decreased phage viability.<ref>PMID:381286</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia phage T5]]
[[Category: Large Structures]]
[[Category: Dzhus UF]]
[[Category: Gabdulkhakov AG]]
[[Category: Glukhov AS]]
[[Category: Selikhanov GK]]