View source for 8qmd


==Human NK cell receptor NKp80, extracellular domain==
<StructureSection load='8qmd' size='340' side='right'caption='[[8qmd]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qmd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmd OCA], [https://pdbe.org/8qmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmd RCSB], [https://www.ebi.ac.uk/pdbsum/8qmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KLRF1_HUMAN KLRF1_HUMAN] Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606).<ref>PMID:17057721</ref> <ref>PMID:21149606</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Blaha J]]
[[Category: Kalouskova B]]
[[Category: Pazderova K]]
[[Category: Vanek O]]
[[Category: Wilmanns M]]