View source for 8qmq


==Succinic semialdehyde dehydrogenase from E. coli with bound NAD+==
<StructureSection load='8qmq' size='340' side='right'caption='[[8qmq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qmq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmq OCA], [https://pdbe.org/8qmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmq RCSB], [https://www.ebi.ac.uk/pdbsum/8qmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAD_ECOLI SAD_ECOLI] Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources.<ref>PMID:17873044</ref> <ref>PMID:20639325</ref> <ref>PMID:7009588</ref> <ref>PMID:7011797</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Erb TJ]]
[[Category: He H]]
[[Category: Zarzycki J]]