View source for 8qmr


==Succinic semialdehyde dehydrogenase from E. coli with bound NAD+ and succinic semialdehyde==
<StructureSection load='8qmr' size='340' side='right'caption='[[8qmr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qmr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SSN:4-OXOBUTANOIC+ACID'>SSN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qmr OCA], [https://pdbe.org/8qmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qmr RCSB], [https://www.ebi.ac.uk/pdbsum/8qmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qmr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAD_ECOLI SAD_ECOLI] Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources.<ref>PMID:17873044</ref> <ref>PMID:20639325</ref> <ref>PMID:7009588</ref> <ref>PMID:7011797</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Erb TJ]]
[[Category: He H]]
[[Category: Zarzycki J]]