View source for 8qms


==Succinic semialdehyde dehydrogenase from E. coli with Q262R substitution and bound NAD+==
<StructureSection load='8qms' size='340' side='right'caption='[[8qms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qms]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QMS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qms OCA], [https://pdbe.org/8qms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qms RCSB], [https://www.ebi.ac.uk/pdbsum/8qms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qms ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAD_ECOLI SAD_ECOLI] Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources.<ref>PMID:17873044</ref> <ref>PMID:20639325</ref> <ref>PMID:7009588</ref> <ref>PMID:7011797</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Erb TJ]]
[[Category: He H]]
[[Category: Zarzycki J]]