View source for 8qoe


==Inward-facing conformation of the ABC transporter BmrA==
<StructureSection load='8qoe' size='340' side='right'caption='[[8qoe]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qoe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QOE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qoe OCA], [https://pdbe.org/8qoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qoe RCSB], [https://www.ebi.ac.uk/pdbsum/8qoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qoe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BMRA_BACSU BMRA_BACSU] An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding causes a large conformational change responsible for substrate translocation (PubMed:18215075). Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).<ref>PMID:18215075</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Di Cesare M]]
[[Category: Hanssen E]]
[[Category: Jault JM]]
[[Category: Kaplan E]]
[[Category: Orelle C]]
[[Category: Valimehr S]]