View source for 8qr1


==Cryo-EM structure of the human Tip60 complex==
<StructureSection load='8qr1' size='340' side='right'caption='[[8qr1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qr1]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QR1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qr1 OCA], [https://pdbe.org/8qr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qr1 RCSB], [https://www.ebi.ac.uk/pdbsum/8qr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qr1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EP400_HUMAN EP400_HUMAN] Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.<ref>PMID:14966270</ref> <ref>PMID:24463511</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ben-Shem A]]
[[Category: Brion A]]
[[Category: Concordet JP]]
[[Category: Crucifix C]]
[[Category: Li C]]
[[Category: Papai G]]
[[Category: Poterszman A]]
[[Category: Schnitzler C]]
[[Category: Schultz P]]
[[Category: Smirnova E]]