View source for 8qxw


==HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2==
<StructureSection load='8qxw' size='340' side='right'caption='[[8qxw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qxw OCA], [https://pdbe.org/8qxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qxw RCSB], [https://www.ebi.ac.uk/pdbsum/8qxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qxw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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</StructureSection>
[[Category: Human betaherpesvirus 5]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Alvisi G]]
[[Category: Aragao D]]
[[Category: Ariawan D]]
[[Category: Cozza G]]
[[Category: Cross EM]]
[[Category: Di Iorio E]]
[[Category: Forwood JK]]
[[Category: Marin O]]