View source for 8qzq


==Single particle cryo-EM co-structure of E. coli AcrB with bound BDM91531 inhibitor==
<StructureSection load='8qzq' size='340' side='right'caption='[[8qzq]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8qzq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WR6:[(2~{R})-1-[[(2~{R})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-undecanoyloxy-propan-2-yl]+tricosanoate'>WR6</scene>, <scene name='pdbligand=XE9:[3-(3-chloranyl-2-piperazin-1-yl-quinolin-6-yl)phenyl]methanamine'>XE9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qzq OCA], [https://pdbe.org/8qzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qzq RCSB], [https://www.ebi.ac.uk/pdbsum/8qzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qzq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Boernsen C]]
[[Category: Frangakis AS]]
[[Category: Mueller RT]]
[[Category: Pos KM]]