View source for 8r7j


==Cryo-EM structure of the human TREX-2 complex==
<StructureSection load='8r7j' size='340' side='right'caption='[[8r7j]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8r7j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R7J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r7j OCA], [https://pdbe.org/8r7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r7j RCSB], [https://www.ebi.ac.uk/pdbsum/8r7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r7j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GANP_HUMAN GANP_HUMAN] Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.<ref>PMID:22307388</ref>   Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.<ref>PMID:22307388</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Graf M]]
[[Category: Hohmann U]]
[[Category: Plaschka C]]