View source for 8raq


==Crystal structure of Mycobacterium tuberculosis MmaA1 with S-adenosyl methionine (SAM)==
<StructureSection load='8raq' size='340' side='right'caption='[[8raq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8raq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RAQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8raq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8raq OCA], [https://pdbe.org/8raq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8raq RCSB], [https://www.ebi.ac.uk/pdbsum/8raq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8raq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMAA1_MYCTU MMAA1_MYCTU] Involved in the conversion of a cis-olefin into a trans-olefin with concomitant introduction of an allylic methyl branch at the proximal position of the precursor to both the methoxy and ketomycolic acids. It directly affects the cis- to trans ratio and indirectly affects the keto to methoxy ratio.<ref>PMID:20472794</ref> <ref>PMID:9092547</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chaudhary B]]
[[Category: Dong G]]
[[Category: Kobakhidze G]]
[[Category: Madhurantakam G]]
[[Category: Mazumdar PA]]
[[Category: Wachelder L]]