View source for 8rcx


==Crystal structure of the Mycobacterium tuberculosis regulator VirS (N-terminal fragment 4-208) in complex with the drug candidate alpibectir==
<StructureSection load='8rcx' size='340' side='right'caption='[[8rcx]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rcx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RCX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.494&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YPQ:4,4,4-tris(fluoranyl)-1-[3-(trifluoromethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]butan-1-one'>YPQ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rcx OCA], [https://pdbe.org/8rcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rcx RCSB], [https://www.ebi.ac.uk/pdbsum/8rcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rcx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VIRS_MYCTU VIRS_MYCTU] Regulates the expression of the mymA operon (Rv3083-Rv3089).<ref>PMID:14568148</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Antoine R]]
[[Category: Barros Aguirre D]]
[[Category: Baulard AR]]
[[Category: Bourotte M]]
[[Category: Dale GE]]
[[Category: Deprez B]]
[[Category: Dreneau A]]
[[Category: Drewes G]]
[[Category: Edoo Z]]
[[Category: Frita R]]
[[Category: Ghidelli-Disse S]]
[[Category: Gitzinger M]]
[[Category: Grosse C]]
[[Category: Hofmann L]]
[[Category: Jung F]]
[[Category: Kemmer C]]
[[Category: Lociuro S]]
[[Category: Mathys V]]
[[Category: Megalizzi V]]
[[Category: Mendoza A]]
[[Category: Moune M]]
[[Category: Perez-Herran E]]
[[Category: Pieren M]]
[[Category: Rebollo Lopez MJ]]
[[Category: Remuinan MD]]
[[Category: Schellhorn B]]
[[Category: Soetaert K]]
[[Category: Trebosc V]]
[[Category: Willand N]]
[[Category: Wintjens R]]