View source for 8rgi


==Structure of DYNLT1:DYNLT2B (TCTEX1:TCTEX1D2) heterodimer.==
<StructureSection load='8rgi' size='340' side='right'caption='[[8rgi]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rgi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rgi OCA], [https://pdbe.org/8rgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rgi RCSB], [https://www.ebi.ac.uk/pdbsum/8rgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rgi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYLT1_HUMAN DYLT1_HUMAN] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.<ref>PMID:18647839</ref>   Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Daly L]]
[[Category: Jenkins D]]
[[Category: Mukhopadhyay AG]]
[[Category: Roberts AJ]]
[[Category: Seda M]]
[[Category: Stephens DJ]]
[[Category: Toropova K]]
[[Category: Vuolo L]]
[[Category: Wells J]]