View source for 8rgx


==Cryo-EM structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis==
<StructureSection load='8rgx' size='340' side='right'caption='[[8rgx]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rgx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RGX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rgx OCA], [https://pdbe.org/8rgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rgx RCSB], [https://www.ebi.ac.uk/pdbsum/8rgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rgx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Afanasyev P]]
[[Category: Boehringer D]]
[[Category: Glockshuber R]]
[[Category: Weber-Ban E]]
[[Category: Zdanowicz R]]
[[Category: Von Rosen T]]