View source for 8rgz


==Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules.==
<StructureSection load='8rgz' size='340' side='right'caption='[[8rgz]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rgz]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_F Human alphaherpesvirus 1 strain F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RGZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rgz OCA], [https://pdbe.org/8rgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rgz RCSB], [https://www.ebi.ac.uk/pdbsum/8rgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rgz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GB_HHV1F GB_HHV1F] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation) (By similarity).<ref>PMID:17548810</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human alphaherpesvirus 1 strain F]]
[[Category: Large Structures]]
[[Category: Arndt M]]
[[Category: Blumenschein E]]
[[Category: Chami M]]
[[Category: Diebolder P]]
[[Category: Eckert D]]
[[Category: Engel R]]
[[Category: Imhof T]]
[[Category: Jenner L]]
[[Category: Kalbermatter D]]
[[Category: Krauss J]]
[[Category: Moog K]]
[[Category: Mueller C]]
[[Category: Ries M]]
[[Category: Schaller T]]
[[Category: Seyfizadeh N]]
[[Category: Yendrzheyevskiy A]]