View source for 8rhj


==Yeast 20S proteasome in complex with a macrocyclic oxindole epoxyketone (compound 5)==
<StructureSection load='8rhj' size='340' side='right'caption='[[8rhj]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rhj]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RHJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VO:(3~{R},4~{S})-4-AZANYL-2,6-DIMETHYL-HEPTANE-2,3-DIOL'>6VO</scene>, <scene name='pdbligand=A1H45:(2~{S})-2-azanyl-3-[(3~{R})-5-oxidanyl-2-oxidanylidene-1,3-dihydroindol-3-yl]propanoic+acid'>A1H45</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPN:PARA-NITROPHENYLALANINE'>PPN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rhj OCA], [https://pdbe.org/8rhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rhj RCSB], [https://www.ebi.ac.uk/pdbsum/8rhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rhj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Synthetic construct]]
[[Category: Dorn R]]
[[Category: Godwin K]]
[[Category: Goetz MG]]
[[Category: Groll M]]
[[Category: Hansen H]]
[[Category: Klemmer W]]
[[Category: Merrill-Steskal G]]
[[Category: Molacek L]]
[[Category: Palmer M]]
[[Category: Price R]]
[[Category: Produturi G]]
[[Category: Rocha M]]
[[Category: Strater Z]]