View source for 8rhk


==Yeast 20S proteasome in complex with a linear oxindole epoxyketone (compound 6)==
<StructureSection load='8rhk' size='340' side='right'caption='[[8rhk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rhk]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RHK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VO:(3~{R},4~{S})-4-AZANYL-2,6-DIMETHYL-HEPTANE-2,3-DIOL'>6VO</scene>, <scene name='pdbligand=A1H2H:(2~{S})-2-azanyl-3-(3-fluoranyl-4-nitro-phenyl)propanoic+acid'>A1H2H</scene>, <scene name='pdbligand=A1H2I:(2~{S})-2-azanyl-3-[(3~{S})-5-oxidanyl-2-oxidanylidene-1,3-dihydroindol-3-yl]propanoic+acid'>A1H2I</scene>, <scene name='pdbligand=A1H45:(2~{S})-2-azanyl-3-[(3~{R})-5-oxidanyl-2-oxidanylidene-1,3-dihydroindol-3-yl]propanoic+acid'>A1H45</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rhk OCA], [https://pdbe.org/8rhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rhk RCSB], [https://www.ebi.ac.uk/pdbsum/8rhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rhk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA7_YEAST PSA7_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Dorn R]]
[[Category: Godwin K]]
[[Category: Goetz MG]]
[[Category: Groll M]]
[[Category: Hansen H]]
[[Category: Klemmer W]]
[[Category: Merrill-Steskal G]]
[[Category: Molacek L]]
[[Category: Palmer M]]
[[Category: Price R]]
[[Category: Produturi G]]
[[Category: Rocha M]]
[[Category: Strater Z]]