View source for 8rhr


==E.coli Peptide Deformylase with bound inhibitor BB4==
<StructureSection load='8rhr' size='340' side='right'caption='[[8rhr]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RHR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB4:2-(5-BROMO-1H-INDOL-3-YL)-N-HYDROXYACETAMIDE'>BB4</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rhr OCA], [https://pdbe.org/8rhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rhr RCSB], [https://www.ebi.ac.uk/pdbsum/8rhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rhr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C3SRA2_ECOLX C3SRA2_ECOLX] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Hofmann E]]
[[Category: Kirschner H]]
[[Category: Stoll R]]