View source for 8rkf


==Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)==
<StructureSection load='8rkf' size='340' side='right'caption='[[8rkf]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rkf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RKF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rkf OCA], [https://pdbe.org/8rkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rkf RCSB], [https://www.ebi.ac.uk/pdbsum/8rkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rkf ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZP2_HUMAN ZP2_HUMAN] Female infertility due to zona pellucida defect. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZP2_HUMAN ZP2_HUMAN] Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).<ref>PMID:29895852</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dioguardi E]]
[[Category: Jovine L]]
[[Category: Stsiapanava A]]
[[Category: De Sanctis D]]