View source for 8rlm


==TRIF Oligomerisation==
<StructureSection load='8rlm' size='340' side='right'caption='[[8rlm]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rlm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RLM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rlm OCA], [https://pdbe.org/8rlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rlm RCSB], [https://www.ebi.ac.uk/pdbsum/8rlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rlm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN] Herpetic encephalitis. Herpes simplex encephalitis 4 (HSE4) [MIM:[https://omim.org/entry/614850 614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:22105173</ref> 
== Function ==
[https://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN] Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.<ref>PMID:12471095</ref> <ref>PMID:12539043</ref> <ref>PMID:14739303</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bryant CE]]
[[Category: Egelman EH]]
[[Category: Gay NJ]]
[[Category: Klenerman D]]
[[Category: Moncrieffe MC]]
[[Category: Soares SG]]
[[Category: Symmoms MF]]
[[Category: Verstak B]]
[[Category: Whitely L]]