View source for 8roi


==Human cohesin SMC3-HD(EQ)/RAD21-C complex - ADP-bound conformation==
<StructureSection load='8roi' size='340' side='right'caption='[[8roi]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8roi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ROI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ROI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8roi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8roi OCA], [https://pdbe.org/8roi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8roi RCSB], [https://www.ebi.ac.uk/pdbsum/8roi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8roi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SMC3_HUMAN SMC3_HUMAN] Cornelia de Lange syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SMC3_HUMAN SMC3_HUMAN] Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.<ref>PMID:11076961</ref> <ref>PMID:19907496</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Romier C]]
[[Category: Vitoria Gomes M]]