View source for 8rp0


==Aminodeoxychorismate synthase complex from Escherichia coli, with glutamine and chorismate added==
<StructureSection load='8rp0' size='340' side='right'caption='[[8rp0]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rp0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RP0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ISJ:(3R,4R)-3-[(1-CARBOXYETHENYL)OXY]-4-HYDROXYCYCLOHEXA-1,5-DIENE-1-CARBOXYLIC+ACID'>ISJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rp0 OCA], [https://pdbe.org/8rp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rp0 RCSB], [https://www.ebi.ac.uk/pdbsum/8rp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rp0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PABA_ECOLI PABA_ECOLI] Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB.<ref>PMID:4914080</ref> <ref>PMID:7592344</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Funke FJ]]
[[Category: Schlee S]]
[[Category: Sterner R]]
[[Category: Sung S]]
[[Category: Wilmanns M]]